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The internal organs of vertebrate species are controlled by the endocrine system, an integrated chemical signaling network. This finely tuned communication system relies on hormones (chemical signals) to maintain complex information flow required for general health. Sometimes environmental elements can alter this system. Often referred to as “endocrine disrupting chemicals,” these false signals mimic or block natural hormones producing unintended effects that threaten the well-being of humans and ecosystems. Species as diverse as snails, turtles, fish, frogs, sheep, polar bears, and humans experience reproductive and developmental effects associated with endocrine disrupting chemicals.
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Endocrine disruption is a manifestation of a larger biological issue – that is, the complex signaling networks that exist within and between organisms. These signaling networks can be maintained or perturbed by environmental factors. Understanding these systems will provide new approaches to health, a coherent view of the environment, and predictive models for environmental change.
Research on the environment and hormones is highly interdisciplinary. CBR with its partners is an international hub for environmental signaling laboratory, field and modeling studies, and a communicator of reliable information to public and professional audiences. For example, since 1990, the Bioenvironmental Hazards project has focused on environmental signaling research with a particular emphasis on real-time biosensor technologies and biomarkers of exposure. The Medicinal Foods project is developing practical methods for maximizing health benefits of long-term consumption of soy and other plant foods. Since 1999, the CBR has hosted the annual Symposium on the Environment and Hormones (e.hormone) to showcase the latest research in this field. This international event is the only conference where a diverse group of scientists address these complex interdisciplinary issues. The CBR has expanded this group by hosting innovative signaling workshops and instituting formal and informal mentorships for junior investigators. A website connecting people to authoritative and reliable research reflects the center’s accessible approach to the science. This research group is known as The Environmental Signaling Network.
- The CBR Biosensors for Defense Applications Program has developed one of the world’s smallest, least expensive biosensors for real-time biohazard monitoring.
- CBR research has discovered an anti-estrogen found in soybeans that may be useful in breast cancer treatment.
- CBR research has uncovered a molecular switch that turns normal uterine muscle cells into fibroid tumors, and holds out hope for treatment of this disease that affects 30% of women.
- CBR scientists and educators have developed curriculum to teach about environmental signaling and endocrine disruption, have taught ES 101 to over 100 college and high school teachers, students, and journalists, and made course modules available on the internet.
- The CBR’s e.hormone website is a nationally and internationally recognized resource for information on the endocrine system and endocrine disruption.
- The Department of Defense, Office of Naval Research
- The United States Department of Agriculture
- The National Science Foundation’s Research Coordination Networks Program
- The National Institute of Health
- The Environmental Protection Agency
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